Pyridines and derivatives
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- (1)
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- (1)
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- (8)
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- (1)
- (1)
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- (1)
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- (1)
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- (1)
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Filtered Search Results
Selleck Chemical LLC Aprepitant S1189-100mg
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0 1 nM Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF IL-6 IL-8 and TNF Aprepitant inhibits HIV infection of human macrophages
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Erucamide (cis-13-Docosenamide) | 112-84-5 | 99.3% | 337.58 | 5 G
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Erucamide (cis-13-Docosenamide) | 112-84-5 | 99.3% | 337.58 | 5 G
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Aobchem AOBCHEM
5000943885 2- 3 4-DICHLORO-5-METHYLPHENYL
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Apexbio Technology LLC FK866 (APO866) 658084-64-1 25mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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FK866 (APO866 CAS 658084-64-1) is a small-molecule inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme involved in NAD biosynthesis FK866 inhibits NMPRTase with reported IC50 values ranging from 0 09 to 27 2 nM Due to elevated NAD turnover in cancer cells inhibition of NAD synthesis selectively induces cell death in cancerous cells FK866 reduces ATP production by decreasing cellular NAD availability resulting in mitochondrial membrane depolarization and caspase-independent cell death Preclinical studies demonstrate activity against hematologic cancer cell lines including AML with minimal toxicity to normal hematopoietic progenitors FK866 suppresses tumor growth in vivo and prolongs survival making it useful in oncology research related to NAD metabolism
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eMolecules 13161-30-3 | HOPO | Ambeed | MFCD00006195 | 111.100 | C5H5NO2 | 98.000 | Oc1cccc[n+]1[O-] | 100g | 552741541
HOPO | Ambeed | 13161-30-3 | MFCD00006195 | 111.100 | C5H5NO2 | 98.000 | Oc1cccc[n+]1[O-] | 100g | 552741541
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Medchemexpress LLC 4-desmethoxy omeprazole | 110374-16-8 | MFCD08272115 | 99.0% | 315.39 | C16H17N3O2S | 5 MG
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4-Desmethoxy Omeprazole is the active metabolite and analytical standard of omeprazole, intended for research and analytical applications including impurity profiling, metabolite studies, and method development. The material is provided as a characterized solid reference with reported high purity and defined molecular properties.
- High purity analytical standard suitable for chromatography and mass spectrometry.
- Intended for impurity identification, metabolite studies, and method validation.
- Available in small milligram-scale quantities appropriate for laboratory use.
- Supplied with CAS, molecular formula, and molecular weight information for traceability.
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Alkali Scientific Luria Broth Miller's Modified, 25 Kilograms
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Luria Broth Miller's Modified, 25 kg, microbial growth media, laboratory use. This modified Luria broth is designed for the growth of bacterial cultures, particularly E. coli and other research strains. It’s an essential medium for genetic, biochemical, and microbiological studies. Its formulation supports high cell density growth, making it ideal for culturing bacteria in large quantities. This 25kg pack ensures an ample supply for extended use in laboratories with demanding research needs.
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Medchemexpress LLC Carboxypeptidase A1/A2/B Antibody (YA2486) | 50 UL
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Carboxypeptidase A1/A2/B Antibody (YA2486) is a monoclonal antibody designed for specific detection of Carboxypeptidase A1/A2/B proteins. This Rabbit-derived, non-conjugated IgG antibody is affinity purified for high specificity.
- Rabbit-derived and non-conjugated IgG monoclonal antibody
- Targets Carboxypeptidase A1/A2/B
- Affinity purified
- Observed band size: 44 kDa
- Predicted band size: 47 kDa
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Medchemexpress LLC Cay10603 | 1045792-66-2 | 99.8% | 446.50 | 1 G
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CAY10603 (BML-281) is a potent and selective HDAC6 inhibitor, with an IC50 of 2 pM. It also inhibits HDAC1, HDAC2, HDAC3, HDAC8, and HDAC10. This compound exhibits potent inhibitory activities against various pancreatic cancer cell lines and induces apoptosis in lung adenocarcinoma cells.
- Potent and selective HDAC6 inhibitor.
- Exhibits potent inhibitory activities against various pancreatic cancer cell lines (e.g., BxPC-3, HupT3, Mia Paca-2, Panc 04.03, SU.86.86, HMEC, HPDE6c7) with IC50s ranging from 0.1 to 1 μM.
- Inhibits HDAC6 deacetylase activity and suppresses the proliferation of lung adenocarcinoma cells.
- Induces apoptosis in lung adenocarcinoma cells.
- Synergizes with gefitinib to induce apoptosis in lung adenocarcinoma cell lines, partially by destabilizing EGFR and inactivating the EGFR pathway.
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Medchemexpress LLC Letermovir | 917389-32-3 | C29H28F4N4O4 | 1 ML
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Letermovir (AIC246) is a potent inhibitor of CMV that targets the viral terminase complex and remains active against viruses resistant to DNA polymerase inhibitors. It inhibits HCMV replication by interfering with the proper cleavage/packaging of HCMV progeny DNA, involving the viral gene product UL56.
- Exhibits consistent antiviral efficacy and remarkable selectivity for human cytomegaloviruses.
- Inhibits HCMV replication by interfering with proper cleavage/packaging of HCMV progeny DNA.
- Superior potency compared to ganciclovir (GCV).
- Additive antiviral effects when combined with anti-HCMV drugs.
- Leads to a dose-dependent reduction of HCMV titer in mouse xenograft models.
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Selleck Chemical LLC Promestriene S3657-5mg
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Promestriene (3-propyl ethyl 17B-methyl estradiol) is a synthetic estrogen analog that has been reported to significantly improve the symptoms of vaginal atrophy caused by estrogen deprivation in topical application
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Selleck Chemical LLC ML351 S3387-5mg
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ML351 is a selective inhibitor of 15-Lipoxygenase-1 (15-LOX-1 or 12/15-LOX) with IC50 of 200 nM
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Medchemexpress LLC Sacubitril (AHU-377) | 149709-62-6 | 99.9% | 411.49 | 100 MG
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Sacubitril (AHU-377) is a potent, orally active neprilysin (NEP) inhibitor with an IC50 of 5 nM. It is a component of the heart failure medicine LCZ696 and is used for the research of heart failure, hypertension, and COVID-19. It enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects.
- Potent and orally active neprilysin (NEP) inhibitor
- IC50 of 5 nM for NEP
- Component of heart failure medicine LCZ696
- Used for research on heart failure, hypertension, and COVID-19
- Enhances natriuretic peptide (NP) system tone
- Exerts significant antihypertensive effects
- Converted to active metabolite LBQ657
- Active metabolite inhibits cardiac myocyte hypertrophy
- Potentiates ANF-induced urinary sodium excretion
- Augments ANP-evoked plasma cGMP levels
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Selleck Chemical LLC Gadobutrol S3497-25mg
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Gadobutrol (Gadovist Gadavist ZK 135079) is a non-ionic macrocyclic gadolinium-based contrast agent (GBCA) that is usedfor tissue contrast enhancement in magnetic resonance imaging (MRI)
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Selleck Chemical LLC Meclofenoxate (Centrophenoxine) HCl S4280-200mg
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Meclofenoxate (Centrophenoxine) HCl is an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer s disease and also inhibits the activity of cholinephosphotransferase
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